ajnl Posted September 20, 2011 Share Posted September 20, 2011 (edited) Online gamers have achieved a feat beyond the realm of Second Life or Dungeons and Dragons: they have deciphered the structure of an enzyme of an AIDS-like virus that had thwarted scientists for a decade. The exploit is published on Sunday in the journal Nature Structural & Molecular Biology, where -- exceptionally in scientific publishing -- both gamers and researchers are honoured as co-authors. Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV. Figuring out the structure of proteins is vital for understanding the causes of many diseases and developing drugs to block them. But a microscope gives only a flat image of what to the outsider looks like a plate of one-dimensional scrunched-up spaghetti. Pharmacologists, though, need a 3-D picture that "unfolds" the molecule and rotates it in order to reveal potential targets for drugs. This is where Foldit comes in. Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids -- the building blocks of proteins -- using a set of online tools. To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks. Cracking the enzyme "provides new insights for the design of antiretroviral drugs," says the study, referring to the lifeline medication against the human immunodeficiency virus (HIV). It is believed to be the first time that gamers have resolved a long-standing scientific problem. "We wanted to see if human intuition could succeed where automated methods had failed," Firas Khatib of the university's biochemistry lab said in a press release. "The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems." One of Foldit's creators, Seth Cooper, explained why gamers had succeeded where computers had failed. "People have spatial reasoning skills, something computers are not yet good at," he said. "Games provide a framework for bringing together the strengths of computers and humans. The results in this week's paper show that gaming, science and computation can be combined to make advances that were not possible before." - http://games.yahoo.c...-161920724.html Edited September 20, 2011 by ajnl Quote Link to comment Share on other sites More sharing options...
TulsaGeoff Posted September 20, 2011 Share Posted September 20, 2011 "The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems." LoL, Unlease the pro gamers! Nice article. Where can we find the HIV game? Quote Link to comment Share on other sites More sharing options...
Chuckun Posted September 20, 2011 Share Posted September 20, 2011 You mean nolifers might actually have helped pro-lifers? xD Quote Link to comment Share on other sites More sharing options...
Administrators daredevil Posted September 20, 2011 Administrators Share Posted September 20, 2011 Where can we find the HIV game? Was wondering same.. Quote Link to comment Share on other sites More sharing options...
TulsaGeoff Posted September 20, 2011 Share Posted September 20, 2011 Was wondering same.. Can we get a server? LoL Quote Link to comment Share on other sites More sharing options...
Administrators daredevil Posted September 20, 2011 Administrators Share Posted September 20, 2011 Can we get a server? LoL Can we get donation... 2 Quote Link to comment Share on other sites More sharing options...
stabak Posted September 20, 2011 Share Posted September 20, 2011 Where can we find the HIV game? http://fold.it/ 1 Quote Link to comment Share on other sites More sharing options...
TulsaGeoff Posted September 20, 2011 Share Posted September 20, 2011 Nice thanks. I'm playing it now. Quote Link to comment Share on other sites More sharing options...
NoGooD Posted September 21, 2011 Share Posted September 21, 2011 AIDS HEADSHOT! Back on topic, this is an awesome use of talent. Never heard of this game til now. Thanks for the info. Quote Link to comment Share on other sites More sharing options...
*goon Posted December 12, 2011 Share Posted December 12, 2011 lol thats pretty interesting ima have to check out that game Quote Link to comment Share on other sites More sharing options...
yourfriend Posted December 12, 2011 Share Posted December 12, 2011 it's a really cool game all things considered. Amazing that it's actually helping with something Quote Link to comment Share on other sites More sharing options...
PiNoY Posted December 12, 2011 Share Posted December 12, 2011 True Quote Link to comment Share on other sites More sharing options...
TulsaGeoff Posted December 12, 2011 Share Posted December 12, 2011 Did anyone beat the tutorial levels? I got stuck on one and quit after a day of DLing it. Quote Link to comment Share on other sites More sharing options...
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