Another thing to consider when you choose a Linux distro is how long you will be able to update the system (for many it's not important but I prefer not to do reinstalls or upgrades when a new version comes).
I use Arch Linux which is a rolling release (i.e. you can update it forever) in fact there are no Arch Linux version numbers, there is only one and you can update it forever.
But Arch Linux is not really user friendly, since sometimes you need to fix or change stuff on your own after updates, not to mention that the whole install took me 2 hours and after that I had just a console with no desktop, nothing, just the core system. Then I had to choose which desktop to use, install and configure everything etc.
You can imagine how many hours it took me to get the final system running
When I used Fedora (and the same is for Ubuntu, but you have lts which lasts longer), after a while I needed to upgrade to the next version or I wouldn't be able to install updates anymore.
And another thing, if it's easy to install proprietary drivers for your gfx card
To install ET, it doesn't make sense to run it on Wine, since you can install the native Linux version.
If your os is 64bit you need to install 32 bit libraries and drivers, plus you need to update punkbuster manually if you want to join servers with pb, but it's not that hard to install, there are tutorials around